THE CONTACT PHASE OF BLOOD COAGULATION

The contact phase of coagulation in the presence of heparin.

The effect of heparin on the contact phase of coagulation has been investigated by a technique utilizing a solution of toluidine blue in calcium chloride. Heparin in a concentration of 7 units/ml. of plasma does not inhibit contact activation by glass. It is suggested that heparin does not prevent the activation of factor XII (Hageman factor) by glass or the subsequent formation of active facto...

A Hitherto Undescribed Plasma Factor Acting at the Contact Phase of Blood Coagulation ( Flaujeac Factor )

This paper reports an asymptomatic coagulation defect responsible for an abnormality at the contact phase of blood coagulation in vitro, distinct from Hageman factor and Fletcher factor deficiencies. Coagulation studies in a 50-yr-old French woman without bleeding tendency revealed the following results: whole-blood clotting time in glass tubes and activated partial thromboplastin time with kao...

A hitherto undescribed plasma factor acting at the contact phase of blood coagulation (Flaujeac factor): case report and coagulation studies.

This paper reports an asymptomatic coagulation defect responsible for an abnormality at the contact phase of blood coagulation in vitro, distinct from Hageman factor and Fletcher factor deficiencies. Coagulation studies in a 50-yr-old French woman without bleeding tendency revealed the following results: whole-blood clotting time in glass tubes and activated partial thromboplastin time with kao...

A Normal Inhibitor of the Blood Coagulation Contact Reaction Product.

A renaissance for the contact system in blood coagulation?

Thromb Haemost 2008; 99: 457–460 Anumber of recent studies call for a reevaluation in our perception of the role of the contact activation system in blood coagulation. The antithrombotic phenotype of factor (F) XII-knockout mice and the identification of RNA and polyphosphates as physiological surfaces for contact activation provide new evidence that the contact system contributes to blood coag...